About 3,000 Palestinians are marching towards an Israeli checkpoint in Hebron, not far from Jewish settlements in the centre of the West Bank city.
The rally is being held to mark the 25th anniversary of the creation of the Islamist militant movement, Hamas.
There were also reports of clashes between protesters with Israeli soldiers elsewhere in the West Bank.
On Thursday, a Palestinian teenager was shot dead by an Israeli border guard at a checkpoint in Hebron.